Itna Karo Na Mujhe Pyar is the story of a couple, Nachiket Khanna (Neil) and Ragini Patel, who are driven apart, ironically because of the intense love they shared. Neil, a doctor and Ragini, a nurse have four kids together but their marriage breaks due to a misunderstanding. Post the divorce, Neil moves to America with two of their kids and Ragini stays back in India with two kids.
Over a period of time, staying away from each other has made Neil an indifferent man, whereas Ragini is still trying to run away from the ghosts of her past relationship. They are constantly reminded of their broken marriage because of the children who are a sign of their past love for each other. However, fate has different plans sketched out for them and their children become the pivotal reason for them to start a new chapter in life. The story is now taken forward by the children, who attempt to bring together their separated parents and make them rediscover love after 15 years.